tag:blogger.com,1999:blog-6914086676454800973.post6923198322133618032..comments2023-10-29T01:46:00.188-08:00Comments on VeggiePharm: Are Microbes in Charge?Tim Steelehttp://www.blogger.com/profile/01611027687223434753noreply@blogger.comBlogger55125tag:blogger.com,1999:blog-6914086676454800973.post-17087073135500712202016-07-03T21:42:29.949-08:002016-07-03T21:42:29.949-08:00Laura
here some mushroom reading for a start:
ht...Laura<br /><br />here some mushroom reading for a start:<br /><br />http://vegetablepharm.blogspot.com/2014/07/the-pharmacy-in-your-backyard.html<br /><br />http://vegetablepharm.blogspot.com/2015/04/magic-mushrooms.html<br /><br />Another good resource is Paul Stamets.<br />https://en.wikipedia.org/wiki/Paul_Stamets<br /><br />You can easily look up more information, also concerning the questions you are asking.Gemmahttps://www.blogger.com/profile/18051515271519007652noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-46006911505992870282016-07-03T16:42:01.860-08:002016-07-03T16:42:01.860-08:00Art,
Pyroluria has many different names: aka Pyr...Art,<br /><br />Pyroluria has many different names: aka Pyrroluria, Pyrroles, Pyrrole Disorder, HPL, Mauve Factor, High Mauve, KPU, KP, Kryptopyrrole, and hemepyrrole. The actual molecule is Hydroxyhemopyrrolin-2-one: referred to as HPL.<br /><br />These search terms should yield more results.<br /><br />It would be fascinating if the double-deficiency in zinc and B6 (whether genetic or not) could be correlated to the action of bacteria (or lack of bacteria) in the gut. I don't think anyone is researching this in a systematic way. (I am certainly *thinking* it!)<br /><br />In hindsight, the pyroluria *manifested* after the serious car accident / mild brain injury. As it is now recognized that, within hours of acquiring a brain injury, one acquires a leaky gut - it would make sense that something may have happened to the gut bacteria or the communication between the gut and brain (bacteria?)<br /><br />Here is good two-part article by Dr. Woody McGinnis, et.al. It does mention gut permeability:<br />http://www.walshinstitute.org/uploads/1/7/9/9/17997321/discerning-mauve-factor-part-1-galley-feb-2008.pdf<br /><br />and<br /><br />http://www.walshinstitute.org/uploads/1/7/9/9/17997321/discerning-the-mauve-factor-part-ii-galley.pdf<br /><br />Also, by Dr. McGinnis:<br />http://www.alternativementalhealth.com/pyroluria-hidden-cause-of-schizophrenia-bipolar-depression-and-anxiety-symptoms-4/<br /><br />Dr. McGinnis' bio:<br />http://www.zoominfo.com/p/Woody-McGinnis/1209010066<br /><br />If you have the time, it would be very interesting to hear your thoughts / reactions to the articles and any correlations to gut info which you may already have.<br /><br />Zinc and B6 are critical co-factors in many, many functions in the body. The double deficiency is a real kicker.<br />LauraAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-44951216560895417632016-07-03T14:52:23.365-08:002016-07-03T14:52:23.365-08:00Dear Gemma,
I would be very interested. I do ador...Dear Gemma,<br /><br />I would be very interested. I do adore them - like hobbits! - especially sauteed in butter.<br /><br />Can you guide me a little more? What is the benefit? What types of 'shrooms? Are they acting as a pre-biotic? How often do you eat them? Raw vs cooked? How would I know they are helping?<br /><br />Are the reishi specific to helping the gut-brain connection? Depression/anxiety?<br /><br />Any articles to read?<br /><br />I'm intrigued.<br /><br />I can get a variety of types at our food co-op. One guy brings in 'shrooms he harvests in the Adirondacks, off of a tree (I forget their name.) Tres expensive.<br />LauraAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-55052528381212075202016-07-03T10:10:17.070-08:002016-07-03T10:10:17.070-08:00Laura
you are an interesting case. Zinc is connec...Laura<br /><br />you are an interesting case. Zinc is connected to the sense of smell indeed, it helps also to the sniffer dogs:<br />www.dailymail.co.uk/sciencetech/article-3549381/Could-canine-SUPER-SNIFFERS-soon-patrol-airports-Zinc-nanoparticles-triple-sense-smell-dogs-works-humans-too.html<br /><br />Will you consider adding some mushrooms (after the PH, of course)? Look at reishi, for instance.<br /><br />Gemmahttps://www.blogger.com/profile/18051515271519007652noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-43788775958469343922016-07-03T08:10:13.979-08:002016-07-03T08:10:13.979-08:00Most bacteria have genes that they can turn on and...Most bacteria have genes that they can turn on and off depending on their food supply or other factors. The science is still young in this area. A bacteria seen as "good" could definitely be "bad" in some circumstances. Other bacteria and yeast, normally harmless, sense when their human host is ill or immune-compromised and the begin to multiply rapidly and create life-threatening infections. It's a real balancing act! Microbes that keep us healthy will also happily kill us, should the situation arise. Tim Steelehttps://www.blogger.com/profile/01611027687223434753noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-55079320946094372522016-07-03T08:06:56.816-08:002016-07-03T08:06:56.816-08:00"Playing in the mud" is just a euphemism..."Playing in the mud" is just a euphemism for not being overly sterile in your life. Things like gardening, mowing the lawn, raking leaves, swimming in a lake, pond, or ocean, hiking in the forest, playing with animals, etc... are all great avenues of acquiring new microbes. Tim Steelehttps://www.blogger.com/profile/01611027687223434753noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-39554323534277816732016-07-03T03:53:23.030-08:002016-07-03T03:53:23.030-08:00Could butyrate producing bacteria be a problem for...Could butyrate producing bacteria be a problem for some autoimmune diseases?<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/25261516<br /><br />In addition, gut microbiota of lupus-prone mice were different between sexes, and an overrepresentation of Lachnospiraceae in females was associated with an earlier onset of and/or more severe lupus symptoms. Clostridiaceae and Lachnospiraceae, both harboring butyrate-producing genera, were more abundant in the gut of lupus-prone mice at specific time points during lupus progression.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-77466601389847630452016-07-03T03:41:41.076-08:002016-07-03T03:41:41.076-08:00Hallo Tim,
what about swimming in a lake? Aren...Hallo Tim,<br /><br />what about swimming in a lake? Aren't there the soil-microbes too? As an adult it's easier to swim in a lake to get microbes than to play in the mud ;). Or do you think swimming in a lake don't has any benefits regarding getting in contact with healthy microbes?<br />Thank you! :)Paulahttps://www.blogger.com/profile/16482157162543536116noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-4582627957300083922016-06-30T18:05:24.753-08:002016-06-30T18:05:24.753-08:00Sorry for the trip to the spam folder, I rescued y...Sorry for the trip to the spam folder, I rescued you!<br /><br />Bees are doing great, two hives this year. Can't wait to see what they are making for me.<br /><br />Thanks for all the info, Art was right...there is literally nothing on pyroluria in PubMed, a couple papers from 1970's psych journals, that's it.<br /><br />Good luck, and keep us posted. Others are searching just as you are, maybe they will find this thread and get answers.<br /><br />Have fun potato hacking!Tim Steelehttps://www.blogger.com/profile/01611027687223434753noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-58635545345684983682016-06-30T16:20:53.990-08:002016-06-30T16:20:53.990-08:00Dear Tim, Art & Gemma,
Thank you very much. I...Dear Tim, Art & Gemma,<br /><br />Thank you very much. I so appreciate your thoughts and I will keep checking in, again, Tim. (I was last year, and then life...yadda,yadda. My husband is the beekeeper who uses organic methods to manage his hives. How are your bees doing?!)<br /><br />I am a firm believer that healing the gut will help with depression and anxiety, and I have taken many steps to do that (one trial: I made 24-hour yogurt using L. infantis to increase serotonin. Thoughts? Try a different bacteria? Multiple types?)<br /><br />The pyroluria info I learned from four very reputable sources. It took 6 months of treating with B6, zinc and other vit/min, and one day I woke up and the sense of smell, that I had virtually lost in the car accident years ago, returned! Zinc works for me! Other profoundly good changes, as well.<br /><br />Pyroluria is not recognized by most doctors.<br /><br />The urine test is either not done by most labs, or they do it wrong, and the results are incorrect.<br /><br />FYI on pyroluria:<br />1. Trudy Scott, The Anti-Anxiety Food Solution, see:<br />http://www.everywomanover29.com/blog/<br /><br />Pyroluria search on her site: http://www.everywomanover29.com/blog/?s=pyroluria<br /><br />Pyroluria questionnaire: http://www.everywomanover29.com/blog/pyroluria-questionnaire-from-the-antianxiety-food-solution/<br /><br />2. Julia Ross, The Mood Cure and the Diet Cure, see: http://www.moodcure.com/ (Trudy Scott received training from Julia Ross)<br /><br />3. Joan Mathews Larson, Depression Free Naturally, see:<br />http://www.joanmathewslarson.com/ (If I had an addiction issue, this is the clinic I would go to. She has an astounding success rate, using food/diet/supplements to balance biochemistry. Stats show that 40% of alcoholics have pyroluria, for ex.)<br /><br />Her book's section on pyroluria: http://joanmathewslarson.com/HRC_2006/Depression_06/D_Hide_In_Closet.htm\<br /><br />4. Dr. William Walsh, Nutrient Power: Heal Your Biochemistry, Heal Your brain. See: http://www.walshinstitute.org/the-book.html<br /><br />He recognized 5 distinct types of depression, each related to a different biochemical imbalance.<br /><br />Dr. Walsh comes from the tradition of orthomolecular doctors (e.g. Dr. Linus Pauling); Dr. Carl Pfeiffer's clinic in Princeton, NJ was famous for helping people with psychiatric and mental disorders to heal, using vitamins, minerals, diet and repeat testing. Dr. Walsh worked with Dr. Pfeiffer for many years, before founding his own clinic.<br /><br />I have begun investigating Dr. Datis Kharrazian, as well. He does offer more specific info on gut-brain / vagus and addressed brain injury, as well.<br /><br />I have read that within hours of receiving a brain injury (mild or otherwise) you are blessed with gut dysbiosis, leaky gut, whatever you want to call it. There is an intimate connection between the brain and the gut via the vagus nerve; injure your brain and the gut follows suit.<br /><br />This guy, Cavin Balaster, got a brain injury in 2011. He blogged. He healed (I think his doctor was Dr. Kharrazian). He says, "Nutrition and supplementation were cornerstone pieces in the process of restoring the communication between my gut and my brain..."<br />http://adventuresinbraininjury.com/rehabilitation-through-nutrition/<br /><br />This info, about the gut-brain connection and the microbiota was unknown when I was injured.<br /><br />Hallelujah it is now!<br /><br />Anyway, I am about to try the potato hack for a few days. My husband and I need to get back to more ferments and I think the potato-thing sounds like it will get me back on track.<br /><br />I look forward to hanging around, again!<br />Laura<br /><br />PS Thank you all for being such great resources for us out here... Art, PLEASE start posting on your blog again!!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-5783749917185436442016-06-30T15:47:12.667-08:002016-06-30T15:47:12.667-08:00@Laura,
I started low dose naltrexone and am in th...@Laura,<br />I started low dose naltrexone and am in the process of titration. I am up to 3 mg and start 4.5 mg tomorrow. I am taking it to see if I can help my immune system as I have Rheumatoid Arthritis and have been trying to control it by diet etc. I ran into a wall and needed some help. I do find it has helped my mood (through the creation of endorphins). Too soon to know anything else but I believe there has been some improvement but very smaĺl. But like I said,I have just begun.navillushttps://www.blogger.com/profile/03882777286503796148noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-69232985985167093692016-06-30T09:58:44.158-08:002016-06-30T09:58:44.158-08:00Interesting advice, Gemma. I searched to see if th...Interesting advice, Gemma. I searched to see if the military has caught on to microdosing magic mushrooms, and could not find anything, although they seem to be a big fan of MDMA (ecstacy) for treating PTSD/anxiety/TBI related problems ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573678/ ).<br /><br />But also, I found that the military is using transcendental meditation for the same thing:<br /><br />"Overall, the findings suggest that TM practice decreases psychotropic medication dosages and improves psychological testing scores compared with matched controls. It is anticipated that this chart review will provide valuable insight into the benefits of TM as a viable treatment modality in military treatment facilities. The retrospective chart review provided a valuable tool for quickly and inexpensively gathering pilot data and aids in guiding the development of future prospective studies. Based on our findings, a prospective randomized clinical trial of TM and its effects on behavioral wellness and psychotropic usage is warranted to determine if TM may serve as a viable supplement to therapy or as an alternative to psychotropic medication therapy." read full text here: https://www.dropbox.com/s/bycsjo8qxlix6el/TM.pdf?dl=0<br />Tim Steelehttps://www.blogger.com/profile/01611027687223434753noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-61965857179072480512016-06-30T09:51:14.424-08:002016-06-30T09:51:14.424-08:00Laura,
Pyroluria is not found in the medical liter...Laura,<br />Pyroluria is not found in the medical literature and as far as I can tell no genes have been identified related to it. That would seem to be good news, as it would suggest that your condition is more treatable.<br /><br />I would agree with Tim and further point out that most of your approaches would alter the relative proportions of existing gut bacteria or supplement with probiotics that don't survive in the gut. That would mean that you could still have problems with dust dysbiosis and need new bacteria not found in fermented foods.<br /><br />You might also look into low dose Naltrexone as a reset for your immune system.<br /><br />Your overall approach seems very sensible.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-82125605850561805332016-06-30T08:57:44.155-08:002016-06-30T08:57:44.155-08:00Another article, by Michael Pollan:
http://www.ne...Another article, by Michael Pollan: <br />http://www.newyorker.com/magazine/2015/02/09/trip-treatmentGemmahttps://www.blogger.com/profile/18051515271519007652noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-70361900366483309742016-06-30T08:53:36.086-08:002016-06-30T08:53:36.086-08:00Laura
Hobbits were very happy. They loved eating ...Laura<br /><br />Hobbits were very happy. They loved eating mushrooms. Do look at them too. Psilocybin is a nice example.<br /><br />This Is What It Feels Like to Treat Depression with Magic Mushrooms<br />http://www.vice.com/read/microdosing-psilocybin-depression-184<br />Gemmahttps://www.blogger.com/profile/18051515271519007652noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-70025830140805285982016-06-30T08:38:35.982-08:002016-06-30T08:38:35.982-08:00Hi Laura - I second your sentiments about the laps...Hi Laura - I second your sentiments about the lapse in new Cooling Inflammation blog posts! <br /><br />I have not looked too deeply into depression, sorry. Working in a military hospital, though, I clearly see the connection between traumatic brain injuries and depression. <br /><br />Any advice I could give you here would just be guessing, and probably involve diet/fiber, but it seems you have a handle on that. <br /><br />Sorry I cannot be more helpful. Good luck!<br />TimTim Steelehttps://www.blogger.com/profile/01611027687223434753noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-33324278114852411342016-06-30T04:59:54.112-08:002016-06-30T04:59:54.112-08:00Tim (and Art),
Have you had any posts dedicated t...Tim (and Art),<br /><br />Have you had any posts dedicated to mild depression / anxiety? Mild depression entered my life when I was in a bad car accident years ago (mild brain injury).<br /><br />For 3 years we've been on a Paleo diet with great results! However, I still struggle with mild depressions and mild anxiety, which is new.<br /><br />I also have pyroluria (genetic issue which robs my body of zinc and B6, so I supplement) and depressions/anxiety is linked to this.<br /><br />We do eat ferments (not enough!): I make 24-hour yogurt, sauerkraut, kombucha.<br /><br />Any thoughts from you (and Art! Miss seeing you on Cooling Inflammation!)<br /><br />Gut-brain connection and vagus nerve info is especially helpful.<br /><br />Thanks so much,<br />LauraAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-20288460811653878372016-06-29T14:57:01.796-08:002016-06-29T14:57:01.796-08:00Just to test my results from research on autoimmun...Just to test my results from research on autoimmune diseases, I searched for the human protein that is targeted by the immune system in Crohn's disease. That antigen can't directly produce antibodies, so I looked for similar proteins that could make related antibodies and found the major protein secreted in urine, Uromodulin. It turns out that urinary tract infections and stones are unusually common in Crohn's. So, I think that Crohn's starts with a UTI/kidney stone and spreads to inflammatory bowel disease. It is similar to Hashimoto's thyroiditis starting from celiac.<br /><br />The takeaway message for anyone with an autoimmune disease is that they all start with gut dysbiosis that compromises immune tolerance at the foundation of autoimmunity. That dysbiosis can be repaired in most people with help from The Potato Hack.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-51653628904743287972016-06-29T10:09:47.406-08:002016-06-29T10:09:47.406-08:00You would not believe the antibiotic use in the mi...You would not believe the antibiotic use in the military. They gave us 6 months of off-label high-dose Cipro as a prevention for anthrax attacks that never happened. Upon discharge, treatment of soldiers is transferred to the VA who loves prescribing anti-psychotic meds. Absolutely no thought given to gut flora, it seems. Tim Steelehttps://www.blogger.com/profile/01611027687223434753noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-77418237140980785262016-06-29T10:07:08.285-08:002016-06-29T10:07:08.285-08:00Yes, it certainly is. Crohn's is sometimes ref...Yes, it certainly is. Crohn's is sometimes referred to as "auoto-inflammatory" meaning both an auto-immune disease as well as inflammatory disease.<br /><br />A few people have turned it around with high fiber diets, but it takes lots of experimenting and testing. I'd hate to try to give advice. Best bet is to eat high fiber diet to avoid things like Crohn's. Once they settle in, they are hard to get rid of, but not impossible. Tim Steelehttps://www.blogger.com/profile/01611027687223434753noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-27586614143523827872016-06-29T09:59:48.037-08:002016-06-29T09:59:48.037-08:00Veterans have an increased risk of inflammatory bo...Veterans have an increased risk of inflammatory bowel diseases, which are all linked to depression, PTSD and suicide. The Potato Hack should be encouraged for all veterans and should be augmented with fecal transplants. This could be a major life and life quality saver.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-87354429063675684432016-06-28T14:36:01.960-08:002016-06-28T14:36:01.960-08:00A friend was just diagnosed with Crohn's disea...A friend was just diagnosed with Crohn's disease. I believe that is an inflammatory condition?Lynnhttps://www.blogger.com/profile/04012064137739052552noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-83886023494580640192016-06-28T09:18:07.359-08:002016-06-28T09:18:07.359-08:00My personal take on environmental and agricultural...My personal take on environmental and agricultural toxins is that they are much less important than damaged gut flora in compromising health. There are very few data supporting any health benefits of eating organic foods. There are many studies showing the benefits of exposure to soil.<br /><br />I agree with Tim's general perspective of not worrying about the details and start eating potatoes.<br /><br />I would also like to see some examination of the impact of eating a minimum amount of potatoes in each potato meal. My own personal experience suggests that my small intestines can convert about one potato's worth of starch (not RS) to blood sugar. Any more than that seems to go to the colon flora. My point is that eating different portion sizes of potatoes will have different results, depending on how much starch and RS actually reaches the colon. Thus, lots of small meals of half potatoes will produce very different results from fewer larger meals of two potatoes. Small meals may starve the gut flora of prebiotic fiber and contribute to constipation. Starch and RS that reach the colon are converted into stool bacteria and avoid constipation.<br /><br />I also think that just-potato meals produce a gut flora that neutralizes the weight set point and facilitates weight change, whereas normal varied diet meals produce gut flora that reinforce the current weight and resist weight loss/gain.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-51238978187773230542016-06-28T09:02:22.231-08:002016-06-28T09:02:22.231-08:00I was struck by your boot camp photo. I think tha...I was struck by your boot camp photo. I think that boot camp is an excellent gut flora conditioner. Persistent exposure to muck flora and a regimented diet produces a gut flora that develops the aggressive side of the immune system, but compromises the suppressive side. The result is an immune system that resists infection, historically the major enemy in combat. Unfortunately, that leads to chronic inflammatory and autoimmunity in veterans. One of the hallmark symptoms of chronic inflammation is depression/enhanced suicide risk. All soldiers leaving the service should be treated with The Potato Hack and supplemented with broad spectrum healthy gut flora.Dr. Art Ayershttps://www.blogger.com/profile/01727664149735013259noreply@blogger.comtag:blogger.com,1999:blog-6914086676454800973.post-46076718532696887672016-06-08T05:22:37.437-08:002016-06-08T05:22:37.437-08:00I watched a fascinationg program on the BBC last n...I watched a fascinationg program on the BBC last night. It was an Horizon program called Why are we getting so fat.<br /><br />One of the first things it dealt with was the Double Variant<br />pf the FTO gene. Apparently if you have 2 copies, then you are 50% more likely to develop obesity.<br /><br />Another item handled was Theresa of Providence Rhode Island, who had gained a considerable amount of weight after a fecal transplant to cure her Clostridium dificile (C-dif) infection. The treatment worked, she had instant relief from the C-dif. The healthy donor who gave the poo sample was her daughter. The sting in the tail was her daughter was overweight/obese. Theresa had a 60 poundweight increase over 2 years. The doctors are not allowed by law to give her another fecal transplant from a very skinny healthy donor, to deal with the second proble.<br /><br />The last item was Dr Tim Spector (UK Gut guy) Wants to do a fecal transplant with the fat busting hormone GLP-1 as it rises substantially in the gut after the transplant (and if I understood it correctly, bring the weight down again.<br /><br />Hope you can get to see it. Hopefully it will be on You Tube soon. Definitely worth watching.<br /><br />Jo tBAnonymousnoreply@blogger.com